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J M Brotchie Selected Research

Dopamine Agonists (Dopamine Agonist)

7/2004Selective blockade of D(3) dopamine receptors enhances the anti-parkinsonian properties of ropinirole and levodopa in the MPTP-lesioned primate.
3/2002Striatal AMPA receptor binding is unaltered in the MPTP-lesioned macaque model of Parkinson's disease and dyskinesia.
7/2001Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha(2) adrenoceptor antagonist idazoxan.

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J M Brotchie Research Topics

Disease

28Parkinson Disease (Parkinson's Disease)
01/2020 - 04/2000
19Dyskinesias (Dyskinesia)
01/2020 - 04/2000
7Parkinsonian Disorders (Parkinsonism)
01/2009 - 10/2000
3Movement Disorders (Movement Disorder)
03/2002 - 07/2000
1Cognitive Dysfunction
01/2020
1Hypokinesia (Bradykinesia)
11/2001
1Catalepsy
11/2001

Drug/Important Bio-Agent (IBA)

16Levodopa (L Dopa)FDA LinkGeneric
01/2020 - 04/2000
16Dopamine (Intropin)FDA LinkGeneric
01/2020 - 04/2000
101- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2007 - 09/2000
4delta Opioid Receptors (delta Opioid Receptor)IBA
01/2007 - 06/2000
4N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
03/2005 - 09/2000
3Opioid Analgesics (Opioids)IBA
01/2007 - 09/2001
3N-Methylaspartate (NMDA)IBA
03/2005 - 10/2000
3Dopamine Agonists (Dopamine Agonist)IBA
07/2004 - 07/2001
3CannabinoidsIBA
12/2001 - 07/2000
2AMPA Receptors (AMPA Receptor)IBA
04/2005 - 03/2002
2Cannabinoid Receptors (Cannabinoid Receptor)IBA
12/2001 - 07/2000
2gamma-Aminobutyric Acid (GABA)IBA
12/2001 - 04/2001
2Opioid Peptides (Opioid Peptide)IBA
11/2001 - 09/2001
2EnkephalinsIBA
11/2001 - 04/2001
2Reserpine (Serpasil)FDA Link
06/2001 - 07/2000
2EndocannabinoidsIBA
06/2001 - 07/2000
25-HT2C Serotonin ReceptorIBA
11/2000 - 06/2000
1Dihydroxyphenylalanine (Dopa)IBA
01/2009
1Prazosin (Minipress)FDA LinkGeneric
01/2009
1PotassiumIBA
10/2007
1Topiramate (Topamax)FDA LinkGeneric
04/2005
1Proteins (Proteins, Gene)FDA Link
04/2005
1traxoprodil mesylateIBA
08/2004
1ropinirole (Requip)FDA LinkGeneric
07/2004
1S 33084IBA
07/2004
1Serotonin (5 Hydroxytryptamine)IBA
11/2002
1Cannabinoid Receptor AgonistsIBA
12/2001
1nabilone (Cesamet)FDA Link
12/2001
1Dihydrotachysterol (AT 10)IBA
11/2001
1Haloperidol (Haldol)FDA LinkGeneric
11/2001
1SCH 23390IBA
11/2001
14- (alpha- (4- allyl- 2,5- dimethyl- 1- piperazinyl)- 3- methoxybenzyl)- N,N- diethylbenzamideIBA
11/2001
1Narcotic Antagonists (Opioid Antagonists)IBA
09/2001
1Adrenergic Receptors (Adrenergic Receptor)IBA
07/2001
1IdazoxanIBA
07/2001
1ApomorphineFDA Link
07/2001
1Norepinephrine (Noradrenaline)FDA LinkGeneric
07/2001
1CB1 Cannabinoid Receptor (CB1 Receptor)IBA
06/2001
1Cannabinoid Receptor AntagonistsIBA
06/2001
1Messenger RNA (mRNA)IBA
06/2001
1N- (1- methyl- 5- indolyl)- N'- (3- pyridyl)ureaIBA
11/2000
1mesulergineIBA
11/2000
1Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
10/2000
1ifenprodilIBA
09/2000
1SK&F 82958 (SKF 82958)IBA
06/2000
1indoleIBA
06/2000
1SB 206553IBA
06/2000

Therapy/Procedure

12Therapeutics
03/2005 - 04/2000